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Article

Association of the MTHFR C677T polymorphism with primary brain tumor risk.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2013

Xu Chen, Yuan Lutao, Tian Hengli, Cao Heli, Chen Shiwen

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) gene plays key roles not only in folate metabolism but also in carcinogenesis. The single nucleotide polymorphism MTHFR C677T has been indicated in the development of various tumors. The effect of the MTHFR C677T polymorphism on brain tumors remains poorly understood. We performed the present meta-analysis and aimed to provide a better understanding of the pathogenesis...

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Identifiers

PMID: 23846816
DOI: 10.1007/s13277-013-0922-9

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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