Article
p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis
1 May 2008
Abstract excerpt
The tumor suppressor gene CDKN1B encodes for a 27-kDa cyclin-dependent kinase inhibitory protein, p27Kip1, which together with its well-established role in the inhibition of cell proliferation, displays additional activities in the control of gene transcription and cell motility. p27Kip1 thus represents a good candidate for a gene therapy approach, especially in those cancers refractory to the conventional...
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