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Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.

Molecular cancer therapeutics - 1 Feb 2015

Chikano Yuri, Domoto Takahiro, Furuta Takuya, Sabit Hemragul, Kitano-Tamura Ayako, Pyko Ilya V, Takino Takahisa, Sai Yoshimichi, Hayashi Yutaka, Sato Hiroshi, Miyamoto Ken-ichi, Nakada Mitsutoshi, Minamoto Toshinari

Abstract excerpt

The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer. We previously reported that inhibition of GSK3β compromises the survival and proliferation of glioblastoma cells,...

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Identifiers

PMID: 25504636
DOI: 10.1158/1535-7163.MCT-14-0479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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