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Article

Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.

Brain research - 13 Dec 2006

Culmsee Carsten, Gasser Edith, Hansen Sabine, Tonn Joerg-Christian, Wagner Ernst, Goldbrunner Roland

Abstract excerpt

The serine/threonine kinase Raf-1 is involved in the regulation of tumor cell survival, proliferation and metastasis formation, and has therefore emerged as a promising target for cancer therapy. In addition, Raf-1 activity mediates proliferation of endothelial cells thereby promoting angiogenesis and invasive growth of various tumors, including highly vascularized malignant glioblastoma. The aim of this study...

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Identifiers

PMID: 17112483
DOI: 10.1016/j.brainres.2006.09.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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