Article
Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.
Oncogene - 21 Nov 2002
Humar Bostjan, Graziano Francesco, Cascinu Stefano, Catalano Vincenzo, Ruzzo Anna M, Magnani Mauro, Toro Tumi, Burchill Tudor, Futschik Matthias E, Merriman Tony, Guilford Parry
Abstract excerpt
Truncating mutations in the gene for the cell to cell adhesion protein E-cadherin are the most consistent genetic alterations observed in sporadic and hereditary diffuse gastric cancer (DGC). In addition to these inactivating mutations, a CDH1 promoter polymorphism at position -160 has been repor...
Topics
- Adenocarcinoma
- Adult
- Aged
- Cadherins
- Case-Control Studies
- Codon
- Down-Regulation
- Exons
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Introns
- Italy
- Linkage Disequilibrium
- Male