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Article

Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.

Oncogene - 21 Nov 2002

Humar Bostjan, Graziano Francesco, Cascinu Stefano, Catalano Vincenzo, Ruzzo Anna M, Magnani Mauro, Toro Tumi, Burchill Tudor, Futschik Matthias E, Merriman Tony, Guilford Parry

Abstract excerpt

Truncating mutations in the gene for the cell to cell adhesion protein E-cadherin are the most consistent genetic alterations observed in sporadic and hereditary diffuse gastric cancer (DGC). In addition to these inactivating mutations, a CDH1 promoter polymorphism at position -160 has been reported to lead to transcriptional downregulation of the gene in vitro. We therefore performed a case-control study to...

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Identifiers

PMID: 12444556
DOI: 10.1038/sj.onc.1205921

Genes

CDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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