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Article

The G/A nucleotide change at cDNA position 2494 in the E-cadherin gene (CDH1): analysis in Italian patients.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2000

Ruzzo Annamaria, Graziano Francesco, Costagliola Antonello, Arduini Federica, Testa Enrica, Bearzi Italo, Cortese Giuliana, De Gaetano Andrea, Andreoni Francesca, Lai Vittorio, Magnani Mauro

Abstract excerpt

Current studies are investigating new E-cadherin gene (CDH1) mutations that may be responsible for diffuse gastric cancer susceptibility. Recently, a novel CDH1 germline variant presenting a G/A nucleotide change at cDNA position 2494 has been found in Japanese patients with familial diffuse gastric cancer. The consequent amino acid variation (Val/Met) may alter the binding activity to beta-catenin and the...

Topics

Adult
Aged
Cadherins
DNA
DNA, Complementary
Down-Regulation
Female
Humans
Italy
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Mutation, Missense

Stomach Neoplasms

Source

Identifiers

PMID: 14610318
DOI: 10.1159/000073844

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14610318-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The G/A nucleotide change at cDNA position 2494 in the E-cadherin gene (CDH1): analysis in Italian patients.PMID 14610318Read ↗

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