Article
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.
Clinical pharmacology and therapeutics - 1 Apr 2007
Blake M J, Gaedigk A, Pearce R E, Bomgaars L R, Christensen M L, Stowe C, James L P, Wilson J T, Kearns G L, Leeder J S
Abstract excerpt
The exponential increase in the number of drugs used to treat infant and childhood illnesses necessitates an understanding of the ontogeny of drug biotransformation for the development of safe and effective therapies. Healthy infants received an oral dose (0.3 mg/kg) of dextromethorphan (DM) at 0.5, 1, 2, 4, 6, and 12 months of age. DM and its major metabolites were measured in urine. CYP2D6 genotype was...
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