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Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children.

Expert opinion on drug metabolism & toxicology - 1 Aug 2011

de Wildt Saskia N

Abstract excerpt

INTRODUCTION: There are profound changes that take place in drug metabolism enzymes during fetal and postnatal development. These changes may significantly impact drug therapy in children. AREAS COVERED: A combination of focused and comprehensive literature searches using PubMed and reference lists (from inception to 7 November 2009) is undertaken to identify reports on in vitro and in vivo development of drug...

Topics

Alcohol Dehydrogenase
Child
Child, Preschool
Cytochrome P-450 Enzyme System
Drug Interactions
Fetal Development
Genetic Variation
Genotype
Humans
Inactivation, Metabolic
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Oxygenases

Pharmacogenetics

Pharmacokinetics

Phenotype

Source

Identifiers

PMID: 21548840
DOI: 10.1517/17425255.2011.577739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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