A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.

doi:10.1111/cts.13380

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.

Clinical and translational science - 1 Oct 2022

Leeder J Steven, Gaedigk Andrea, Wright Krista J, Staggs Vincent S, Soden Sarah E, Lin Yvonne S, Pearce Robin E

Abstract excerpt

CYP2D6 substrates are among the most highly prescribed medications in teenagers and also commonly associated with serious adverse events. To investigate the relative contributions of genetic variation, growth, and development on CYP2D6 activity during puberty, healthy children and adolescents 7-15 years of age at enrollment participated in a longitudinal phenotyping study involving administration of 0.3 mg/kg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Cytochrome P-450 CYP2D6
Share to Dextromethorphan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longitudinal Studies

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 35997001
DOI: 10.1111/cts.13380
PMCID: PMC9579386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.