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Article

Expression of <i>CYP2D6</i> in developing human liver

1 Dec 1991

Abstract excerpt

The CYP2D6 protein is a polymorphic isoenzyme involved in the biotransformation of several drugs including the probe drug dextromethorphan. The rise in the protein concentration, immunochemically determined with a specific antibody, was shown to occur within the first week following birth, whatever the gestational age at birth. In fetuses, the concentration of hepatic CYP2D6 protein was very low or undetectable...

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Identifiers

PMID: 1722149
DOI: 10.1111/j.1432-1033.1991.tb16411.x

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