Selection of an attenuated Coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen.

doi:10.1128/JVI.65.3.1286-1290.1991

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Article

Selection of an attenuated Coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen.

Journal of virology - 1 Mar 1991

Van Houten N, Bouchard P E, Moraska A, Huber S A

Abstract excerpt

Previously, we described a heart-reactive monoclonal antibody (MAb), 10A1, derived from a coxsackievirus B3 (CVB3)-infected mouse. This MAb selectively inhibits infection of HeLa cells and myocytes with the myocarditic virus variant (CVB3W). A plaque-purified variant (H3) of CVB3W was isolated from the heart of an infected animal, and a second virus (H3-10A1) was obtained by growing H3 in HeLa cells in the...

Topics

Animals
Animals, Newborn
Antibodies, Monoclonal
Antigens, Viral
Cells, Cultured
Coxsackievirus Infections
Enterovirus B, Human
Genetic Variation
HeLa Cells
Heart
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Leucine

Male

Mice

Mice, Inbred BALB C

Myocardium

Uridine

Source

Open in PubMed Open full text

Identifiers

PMID: 1847455
DOI: 10.1128/JVI.65.3.1286-1290.1991
PMCID: PMC239903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1847455-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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