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Mutant p53 oncogenicity: dominant-negative or gain-of-function?

1 Nov 2020

Abstract excerpt

The p53 protein is mutated in about 50% of human cancers. Aside from losing its tumor-suppressive activities, mutant p53 may acquire pro-oncogenic activity, which is facilitated by two underlying mechanisms. The first mechanism is the inhibition of co-expressed wild-type p53 (WTp53) activity, dubbed the dominant-negative effect (DNE). The second mechanism is a neomorphic pro-oncogenic activity that does not...

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PMID: 33159515
DOI: 10.1093/carcin/bgaa117

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