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Article

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

Development (Cambridge, England) - 1 Mar 2004

Whitehead Kevin J, Plummer Nicholas W, Adams Jennifer A, Marchuk Douglas A, Li Dean Y

Abstract excerpt

Hemorrhagic stroke is a significant cause of morbidity and mortality in children, and is frequently associated with intracranial vascular malformations. One prevalent form of these vascular malformations, cerebral cavernous malformation, is characterized by thin-walled vascular cavities that hemorrhage and has been linked to loss-of-function mutations in CCM1. The neural and epithelial expression of CCM1 in...

Topics

Animals
Arteries
Heart
Hemangioma, Cavernous, Central Nervous System
Humans
KRIT1 Protein
Mice
Microtubule-Associated Proteins
Mutation
Proto-Oncogene Proteins
Receptor, Notch4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cell Surface

Receptors, Notch

Source

Identifiers

PMID: 14993192
DOI: 10.1242/dev.01036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14993192-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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