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Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes

11 May 2021

Abstract excerpt

BACKGROUND: The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration structure. However, the key components of this pathway remain unclear. METHODS: Using the Drosophila nephrocyte as a genetic screen platform, we screened most genes...

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PMID: 33975644
DOI: 10.1186/s13578-021-00595-4

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