Decreased catalytic subunit mRNA levels and altered catalytic subunit mRNA structure in a cAMP-resistant Chinese hamster ovary cell line.

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Article

Decreased catalytic subunit mRNA levels and altered catalytic subunit mRNA structure in a cAMP-resistant Chinese hamster ovary cell line.

The Journal of biological chemistry - 5 Jun 1991

Howard P, Day K H, Kim K E, Richardson J, Thomas J, Abraham I, Fleischmann R D, Gottesman M M, Maurer R A

Abstract excerpt

The mechanisms responsible for decreased levels of cAMP-dependent protein kinase activity in a mutant Chinese hamster ovary cell line have been examined. The cAMP-resistant Chinese hamster ovary 10260 cell line was found to possess only 20% of the cAMP-dependent protein kinase activity found in wild-type cells. The presence of decreased concentrations of the catalytic subunit in these cells was confirmed through...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Catalysis
Cell Line
Chromatography, Gel
Cricetinae
Cricetulus
Cyclic AMP
DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Polymerase Chain Reaction

Protein Kinase Inhibitors

Protein Kinases

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1645343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645343-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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