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Decreased catalytic subunit mRNA levels and altered catalytic subunit mRNA structure in a cAMP-resistant Chinese hamster ovary cell line.

The Journal of biological chemistry - 5 Jun 1991

Howard P, Day K H, Kim K E, Richardson J, Thomas J, Abraham I, Fleischmann R D, Gottesman M M, Maurer R A

Abstract excerpt

The mechanisms responsible for decreased levels of cAMP-dependent protein kinase activity in a mutant Chinese hamster ovary cell line have been examined. The cAMP-resistant Chinese hamster ovary 10260 cell line was found to possess only 20% of the cAMP-dependent protein kinase activity found in wild-type cells. The presence of decreased concentrations of the catalytic subunit in these cells was confirmed through...

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PMID: 1645343

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