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Article

A PP2A active site mutant impedes growth and causes misregulation of native catalytic subunit expression.

Journal of cellular biochemistry - 1 Mar 2008

Lizotte Donna L, Blakeslee Joshua J, Siryaporn Albert, Heath Jeffrey T, DeLong Alison

Abstract excerpt

Activity of protein phosphatase 2A (PP2A) is tightly regulated and performs a diverse repertoire of cellular functions. Previously we isolated a dominant-negative active site mutant of the PP2A catalytic (C) subunit using a yeast complementation assay. We have established stable fibroblastic cell lines expressing epitope-tagged versions of the wild-type and H118N mutant C subunits and have used these cells to...

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PMID: 17803193
DOI: 10.1002/jcb.21514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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