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Article

The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.

Biophysical journal - 1 Dec 2010

Nagatomo Katsuhiro, Ishii Hiroshi, Yamamoto Tomomi, Nakajo Koichi, Kubo Yoshihiro

Abstract excerpt

The transient receptor potential A1 channel (TRPA1) is activated by various compounds, including isothiocyanates, menthol, and cinnamaldehyde. The sensitivities of the rodent and human isoforms of TRPA1 to menthol and the cysteine-attacking compound CMP1 differ, and the molecular determinants for these differences have been identified in the 5th transmembrane region (TM5) for menthol and TM6 for CMP1. We recently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21112285
DOI: 10.1016/j.bpj.2010.10.014
PMCID: PMC2998636

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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