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Article

The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children.

Clinical endocrinology - 1 Nov 2008

Burghardt Hans, López-Bermejo Abel, Baumgartner Bernhard, Ibáñez Lourdes, Vendrell Joan, Ricart Wifredo, Palacín Manuel, Fernández-Real José Manuel, Zorzano Antonio

Abstract excerpt

OBJECTIVE: The amplified in breast cancer-3 protein (AIB3) is a nuclear coactivator involved in proliferation, apoptosis and development. AIB3 loss of function causes deficient insulin secretion in mice, indicating that AIB3 participates in beta-cell regulation. Our objective was to evaluate genetic variants located on AIB3 associated with beta-cell function in children and to analyse the effect of AIB3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18462265
DOI: 10.1111/j.1365-2265.2008.03232.x

Genes

INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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