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Article

Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression.

Biochemical and biophysical research communications - 19 Feb 2010

Meng Xiangning, Kondo Motoyuki, Morino Katsutaro, Fuke Tomoya, Obata Toshiyuki, Yoshizaki Takeshi, Ugi Satoshi, Nishio Yoshihiko, Maeda Shiro, Araki Eiichi, Kashiwagi Atsunori, Maegawa Hiroshi

Abstract excerpt

Down-regulation of insulin receptor substrate-1 (IRS-1) expression could modify the ability of IRS-1 to fulfill its functions. It has been proposed that the phosphorylation of IRS-1 on serine residues could promote its degradation. However, few studies have investigated the transcriptional regula...

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PMID: 20097161
DOI: 10.1016/j.bbrc.2010.01.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20097161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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