Article
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.
Nature genetics - 1 Mar 2000
Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, Hani E H, Vionnet N, Nicod P, Boutin P, Froguel P
Abstract excerpt
Type 2 diabetes is a polygenic and genetically heterogeneous disease . The age of onset of the disease is usually late and environmental factors may be required to induce the complete diabetic phenotype. Susceptibility genes for diabetes have not yet been identified. Islet-brain-1 (IB1, encoded by MAPK8IP1), a novel DNA-binding transactivator of the glucose transporter GLUT2 (encoded by SLC2A2), is the homologue...
Topics
- Adaptor Proteins, Signal Transducing
- Age of Onset
- Apoptosis
- Colony-Forming Units Assay
- Diabetes Mellitus, Type 2
- Female
- Founder Effect
- France
- Genetic Predisposition to Disease
- Genotype