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Article

Defective functions of HNF1A variants on BCL2L1 transactivation and beta-cell growth.

Biochemical and biophysical research communications - 27 Aug 2020

Sujjitjoon Jatuporn, Charoensuk Chutima, Thanyaphon Thanita, Kooptiwut Suwattanee, Thamtarana Prapaporn Jungtrakoon, Tangjittipokin Watip, Chongjaroen Nalinee, Chanprasert Chutima, Abubakar Zuroida, Lapbenjakul Sorravis, Yenchitsomanus Pa-Thai, Plengvidhya Nattachet

Abstract excerpt

Maturity-onset diabetes of the young type 3 (MODY3) is caused by mutations in a gene encoding transcription factor hepatocyte nuclear factor 1-alpha (HNF1A). Although the roles of HNF1A in regulation of hepatic and pancreatic genes to maintain glucose homeostasis were investigated, the functions of HNF1A are not completely elucidated. To better understand the functions of HNF1A, we characterized mutations of...

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Identifiers

PMID: 32684311
DOI: 10.1016/j.bbrc.2020.05.155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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