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Article

Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.

British journal of cancer - 1 May 1999

Li G, Szewczuk M R, Raptis L, Johnson J G, Weagle G E, Pottier R H, Kennedy J C

Abstract excerpt

All nucleated mammalian cells synthesize protoporphyrin IX (PpIX) when exposed to exogenous 5-aminolevulinic acid (ALA). The response to exogenous ALA under standard conditions (the ALA phenotype) is characteristic for each cell type. Significantly more PpIX accumulates in malignant and premalignant cells than in the normal cells from which they were derived. A rodent fibroblast model was developed to study the...

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Identifiers

PMID: 10360643
DOI: 10.1038/sj.bjc.6690409
PMCID: PMC2362266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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