Article
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.
British journal of cancer - 1 May 1999
Li G, Szewczuk M R, Raptis L, Johnson J G, Weagle G E, Pottier R H, Kennedy J C
Abstract excerpt
All nucleated mammalian cells synthesize protoporphyrin IX (PpIX) when exposed to exogenous 5-aminolevulinic acid (ALA). The response to exogenous ALA under standard conditions (the ALA phenotype) is characteristic for each cell type. Significantly more PpIX accumulates in malignant and premalignant cells than in the normal cells from which they were derived. A rodent fibroblast model was developed to study the...
Topics
- 3T3 Cells
- Aminolevulinic Acid
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Female
- Fibroblasts
- Fibrosarcoma
- Flow Cytometry
- Fluorescent Dyes
- Humans
- Lung Neoplasms
- Mice