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A methyl‐deficient diet modifies histone methylation and alters <i>Igf2</i> and <i>H19</i> repression in the prostate

5 May 2008

Abstract excerpt

BACKGROUND: Folate and methyl-group deficiency has been linked to prostate cancer susceptibility, yet the mechanisms underlying these observations are incompletely understood. The region of the genome containing the imprinted genes insulin-like growth factor 2 (Igf2) and H19, both of which display oncogenic functions, may be particularly sensitive to environmental influences. METHODS: To determine whether a...

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PMID: 18459101
DOI: 10.1002/pros.20782

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A methyl‐deficient diet modifies histone methylation and alters <i>Igf2</i> and <i>H19</i> repression in the prostatePMID 18459101Read ↗

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