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Article

Association of maternal and nutrient supply line factors with DNA methylation at the imprinted <i>IGF2/H19</i> locus in multiple tissues of newborn twins

5 Aug 2013

Abstract excerpt

Epigenetic events are crucial for early development, but can be influenced by environmental factors, potentially programming the genome for later adverse health outcomes. The insulin-like growth factor 2 (IGF2)/H19 locus is crucial for prenatal growth and the epigenetic state at this locus is environmentally labile. Recent studies have implicated maternal factors, including folate intake and smoking, in the...

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PMID: 23917818
DOI: 10.4161/epi.25908

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