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Article

Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia.

Epigenetics - 1 Jan 2013

Glier Melissa B, Ngai Ying F, Sulistyoningrum Dian C, Aleliunas Rika E, Bottiglieri Teodoro, Devlin Angela M

Abstract excerpt

DNA methylation is linked to homocysteine metabolism through the generation of S-adenosylmethionine (AdoMet) and S-Adenosylhomocysteine (AdoHcy). The ratio of AdoMet/AdoHcy is often considered an indicator of tissue methylation capacity. The goal of this study is to determine the relationship of tissue AdoMet and AdoHcy concentrations to allele-specific methylation and expression of genomically imprinted...

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Identifiers

PMID: 23221482
DOI: 10.4161/epi.23063
PMCID: PMC3549880

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DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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