Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?

doi:10.1016/j.cardiores.2005.03.005

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Article

Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?

Cardiovascular research - 15 Aug 2005

Meregalli Paola G, Wilde Arthur A M, Tan Hanno L

Abstract excerpt

After its recognition as a distinct clinical entity, Brugada syndrome is increasingly recognized worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits autosomal dominant inheritance with SCN5A, which encodes the cardiac sodium channel, as the only gene with a proven involvement in 20-30% of patients. Its signature feature is ST segment elevation in right precordial ECG leads and...

Topics

Bundle-Branch Block
Death, Sudden, Cardiac
Electrocardiography
Genetic Predisposition to Disease
Heart Conduction System
Humans
Models, Animal
Muscle Proteins
Mutation
NAV1.5 Voltage-Gated Sodium Channel
Sodium Channels
Syncope
Syndrome
Tachycardia, Ventricular

Source

Open in PubMed

Identifiers

PMID: 15913579
DOI: 10.1016/j.cardiores.2005.03.005

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