Mechanisms of disease: current understanding and future challenges in Brugada syndrome.

doi:10.1038/ncpcardio0268

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Article

Mechanisms of disease: current understanding and future challenges in Brugada syndrome.

Nature clinical practice. Cardiovascular medicine - 1 Aug 2005

Shimizu Wataru, Aiba Takeshi, Kamakura Shiro

Abstract excerpt

Brugada syndrome is a clinical entity characterized by ST-segment elevation in the right precordial leads (V1-V3) and an episode of ventricular fibrillation in the absence of structural heart disease. Data regarding genotype-phenotype relationships are limited, since SCN5A, the gene encoding the...

Topics

Bundle-Branch Block
Electrocardiography
Genotype
Humans
Mutation
Phenotype
Sodium Channels
Syndrome
Tachycardia, Ventricular
Ventricular Fibrillation

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