Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch.

doi:10.1016/j.hrthm.2009.10.007

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Article

Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch.

Heart rhythm - 1 Jan 2010

Hoogendijk Mark G, Potse Mark, Linnenbank André C, Verkerk Arie O, den Ruijter Hester M, van Amersfoorth Shirley C M, Klaver Eva C, Beekman Leander, Bezzina Connie R, Postema Pieter G, Tan Hanno L, Reimer Annette G, van der Wal Allard C, Ten Harkel Arend D J, Dalinghaus Michiel, Vinet Alain, Wilde Arthur A M, de Bakker Jacques M T, Coronel Ruben

Abstract excerpt

BACKGROUND: The Brugada sign has been associated with mutations in SCN5A and with right ventricular structural abnormalities. Their role in the Brugada sign and the associated ventricular arrhythmias is unknown. OBJECTIVE: The purpose of this study was to delineate the role of structural abnormalities and sodium channel dysfunction in the Brugada sign. METHODS: Activation and repolarization characteristics of the...

Topics

Adolescent
Ajmaline
Anti-Arrhythmia Agents
Brugada Syndrome
Cardiomyopathy, Dilated
Chromatography, High Pressure Liquid
Computer Simulation
Electrocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrophysiologic Techniques, Cardiac

Female

Genetic Predisposition to Disease

Heart Transplantation

Humans

In Vitro Techniques

Lamin Type A

Muscle Proteins

Mutation

NAV1.5 Voltage-Gated Sodium Channel

Source

Open in PubMed

Identifiers

PMID: 20022821
DOI: 10.1016/j.hrthm.2009.10.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20022821-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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