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Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis

2022-08-31

Abstract excerpt

The RNA editing enzyme Adenosine deaminase acting on RNA 1 (ADAR1) is an essential regulator of innate immune activation by both cellular and viral dsRNA. Adenosine-to-Inosine (A-to-I) editing by ADAR1 modifies the sequence and structure of endogenous dsRNA and masks it from the cytoplasmic dsRNA sensor melanoma differentiation-associated protein 5 (MDA5), preventing innate immune activation. Loss of function muta...

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Literature Corpus work
db103a14-c573-55c3-b6a9-2d8ccf70d8ab
DOI
10.1101/2022.08.31.506069
Open publication

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Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasisDOI 10.1101/2022.08.31.506069
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