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Article

Repression of human activation induced cytidine deaminase by miR-93 and miR-155

10 Aug 2011

Abstract excerpt

BACKGROUND: Activation Induced cytidine Deaminase (AID) targets the immunoglobulin genes of activated B cells, where it converts cytidine to uracil to induce mutagenesis and recombination. While essential for immunoglobulin gene diversification, AID misregulation can result in genomic instability and oncogenic transformation. This is classically illustrated in Burkitt's lymphoma, which is characterized by...

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PMID: 21831295
DOI: 10.1186/1471-2407-11-347

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