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Article

The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 1997

Street V A, Bosma M M, Demas V P, Regan M R, Lin D D, Robinson L C, Agnew W S, Tempel B L

Abstract excerpt

The opisthotonos (opt) mutation arose spontaneously in a C57BL/Ks-db2J colony and is the only known, naturally occurring allele of opt. This mutant mouse was first identified based on its ataxic and convulsive phenotype. Genetic and molecular data presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, which serves as an IP3-gated channel to release calcium from...

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PMID: 8987786
PMCID: PMC6573232

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