Article
The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 1997
Street V A, Bosma M M, Demas V P, Regan M R, Lin D D, Robinson L C, Agnew W S, Tempel B L
Abstract excerpt
The opisthotonos (opt) mutation arose spontaneously in a C57BL/Ks-db2J colony and is the only known, naturally occurring allele of opt. This mutant mouse was first identified based on its ataxic and convulsive phenotype. Genetic and molecular data presented here demonstrate that the type 1 inosit...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium
- Calcium Channels
- Cerebellar Ataxia
- Cerebellum
- DNA Mutational Analysis
- Epilepsy
- Exons
- GTP-Binding Proteins
- Gene Expression Regulation
- Genes
- Genes, Recessive
- Genotype