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Article

Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis.

The Journal of biological chemistry - 23 Dec 2005

Shi Yihui, Vaden Deirdre L, Ju Shulin, Ding Daobin, Geiger James H, Greenberg Miriam L

Abstract excerpt

In a genetic screen for Saccharomyces cerevisiae mutants hypersensitive to the inositol-depleting drugs lithium and valproate, a loss of function allele of TPI1 was identified. The TPI1 gene encodes triose phosphate isomerase, which catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate. A single mutation (N65K) in tpi1 completely abolished Tpi1p enzyme activity and led...

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Source

Identifiers

PMID: 16221686
DOI: 10.1074/jbc.M505181200

Genes

TPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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