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Article

Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea.

The Journal of biological chemistry - 16 May 2003

Berry Gerard T, Wu Shuang, Buccafusca Roberto, Ren Jun, Gonzales Linda W, Ballard Philip L, Golden Jeffrey A, Stevens Martin J, Greer John J

Abstract excerpt

myo-Inositol (Ins) and its polyphosphoinositide derivatives that are important in membrane signaling have long been held to play a special role in brain metabolism. As polyphosphoinositides turn over rapidly and are exceptionally abundant in nervous tissue, high Ins levels in the range of 2-15 mm that have been observed in brain may be necessary to maintain the rates of phosphoinositide synthesis in diverse...

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Identifiers

PMID: 12582158
DOI: 10.1074/jbc.M213176200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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