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Article

Investigations of valanimycin biosynthesis: elucidation of the role of seryl-tRNA.

Proceedings of the National Academy of Sciences of the United States of America - 6 May 2008

Garg Ram P, Qian Xuelei L, Alemany Lawrence B, Moran Sean, Parry Ronald J

Abstract excerpt

The antibiotic valanimycin is a naturally occurring azoxy compound produced by Streptomyces viridifaciens MG456-hF10. Precursor incorporation experiments showed that valanimycin is derived from l-valine and l-serine via the intermediacy of isobutylamine and isobutylhydroxylamine. Enzymatic and genetic investigations led to the cloning and sequencing of the valanimycin biosynthetic gene cluster, which was found to...

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Identifiers

PMID: 18451033
DOI: 10.1073/pnas.0708957105
PMCID: PMC2373340

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