Article
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics.
Chemistry & biology - 1 Jun 2001
Weitnauer G, Mühlenweg A, Trefzer A, Hoffmeister D, Süssmuth R D, Jung G, Welzel K, Vente A, Girreser U, Bechthold A
Abstract excerpt
BACKGROUND: Streptomyces viridochromogenes Tü57 is the producer of avilamycin A. The antibiotic consists of a heptasaccharide side chain and a polyketide-derived dichloroisoeverninic acid as aglycone. Molecular cloning and characterization of the genes governing the avilamycin A biosynthesis is of major interest as this information might set the direction for the development of new antimicrobial agents. RESULTS:...
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