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Article

Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability.

The EMBO journal - 3 Feb 2003

Beebe Kirk, Ribas De Pouplana Lluis, Schimmel Paul

Abstract excerpt

Editing of misactivated amino acids by class I tRNA synthetases is encoded by a specialized internal domain specific to class I enzymes. In contrast, little is known about editing activities of the structurally distinct class II enzymes. Here we show that the class II alanyl-tRNA synthetase (AlaRS) has a specialized internal domain that appears weakly related to an appended domain of threonyl-tRNA synthetase...

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Share to Adenosine Triphosphate
Share to Cell Survival
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Point Mutation

Share to Protein Structure, Tertiary

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Share to RNA, Transfer

Share to Sequence Alignment

Source

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Identifiers

PMID: 12554667
DOI: 10.1093/emboj/cdg065
PMCID: PMC140749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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