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Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing <i>Streptomyces</i> sp. Strain ATCC 700974

1 Sept 2009

Abstract excerpt

The Trojan horse antibiotic albomycin, produced by Streptomyces sp. strain ATCC 700974, contains a thioribosyl nucleoside moiety linked to a hydroxamate siderophore through a serine residue. The seryl nucleoside structure (SB-217452) is a potent inhibitor of seryl-tRNA synthetase (SerRS) in the pathogenic bacterium Staphylococcus aureus, with a 50% inhibitory concentration (IC(50)) of approximately 8 nM. In the...

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PMID: 19721072
DOI: 10.1128/aac.00782-09

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