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Article

Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module.

The Journal of biological chemistry - 8 May 2015

Yan Wei, Ye Qing, Tan Min, Chen Xi, Eriani Gilbert, Wang En-Duo

Abstract excerpt

A conserved structural module following the KMSKS catalytic loop exhibits α-α-β-α topology in class Ia and Ib aminoacyl-tRNA synthetases. However, the function of this domain has received little attention. Here, we describe the effect this module has on the aminoacylation and editing capacities of leucyl-tRNA synthetases (LeuRSs) by characterizing the key residues from various species. Mutation of highly...

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Identifiers

PMID: 25817995
DOI: 10.1074/jbc.M115.639492
PMCID: PMC4424357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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