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Article

Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis.

PloS one - 1 Jan 2016

Ravishankar Sudha, Ambady Anisha, Swetha Rayapadi G, Anbarasu Anand, Ramaiah Sudha, Sambandamurthy Vasan K

Abstract excerpt

Discovery of mupirocin, an antibiotic that targets isoleucyl-tRNA synthetase, established aminoacyl-tRNA synthetase as an attractive target for the discovery of novel antibacterial agents. Despite a high degree of similarity between the bacterial and human aminoacyl-tRNA synthetases, the selectivity observed with mupirocin triggered the possibility of targeting other aminoacyl-tRNA synthetases as potential drug...

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PMID: 26794499
DOI: 10.1371/journal.pone.0147188
PMCID: PMC4721953

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