Article
Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration.
Journal of Alzheimer's disease : JAD - 1 Jan 2012
Villa Chiara, Ghezzi Laura, Fenoglio Chiara, Clerici Francesca, Marcone Alessandra, Benussi Luisa, Ghidoni Roberta, Gallone Salvatore, Serpente Maria, Cantoni Claudia, Ridolfi Elisa, Bonsi Rossana, Cerami Chiara, Cappa Stefano, Binetti Giuliano, Franceschi Massimo, Rainero Innocenzo, Mariani Claudio, Bresolin Nereo, Scarpini Elio, Galimberti Daniela
Abstract excerpt
Transcription factor Sp4 (Specificity protein 4) levels are increased in the brain of patients with Alzheimer's disease (AD), and Sp4 colocalizes with neurofibrillary tangles. Moreover, SP4 is a susceptibility gene for bipolar disorder and schizophrenia, which share many clinical features with frontotemporal lobar degeneration (FTLD). The distribution of three tagging single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.