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Article

Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Villa Chiara, Ridolfi Elisa, Fenoglio Chiara, Ghezzi Laura, Vimercati Roberto, Clerici Francesca, Marcone Alessandra, Gallone Salvatore, Serpente Maria, Cantoni Claudia, Bonsi Rossana, Cioffi Sara, Cappa Stefano, Franceschi Massimo, Rainero Innocenzo, Mariani Claudio, Scarpini Elio, Galimberti Daniela

Abstract excerpt

Altered gene expression occurs in central nervous system disorders, including Alzheimer's disease (AD). Transcription factor Sp1 (specificity protein 1) can regulate the expression of several AD-related proteins, including amyloid-β protein precursor and tau. Sp1 is regulated by oxidative stress, and Sp1 mRNA was found to be upregulated in AD cortex and hippocampus. The distribution of three single nucleotide...

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PMID: 23435408
DOI: 10.3233/JAD-122263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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