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Article

Maternal smoking and oral clefts: the role of detoxification pathway genes.

Epidemiology (Cambridge, Mass.) - 1 Jul 2008

Lie Rolv T, Wilcox Allen J, Taylor Jack, Gjessing Håkon K, Saugstad Ola Didrik, Aabyholm Frank, Vindenes Halvard

Abstract excerpt

BACKGROUND: There is evidence for an effect of cigarette smoking on risk of oral clefts. There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke. METHODS: We performed a combined case-control and family-triad study of babies born with oral clefts in Norway in the period 1996 to 2001, with 88% participation among cases (n = 573) and 76% participation among controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18449058
DOI: 10.1097/EDE.0b013e3181690731
PMCID: PMC5560035

Genes

NAT2
GSTM1
GSTP1
GSTT1
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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