Article
Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction.
Epidemiology (Cambridge, Mass.) - 1 Sept 2001
van Rooij I A, Wegerif M J, Roelofs H M, Peters W H, Kuijpers-Jagtman A M, Zielhuis G A, Merkus H M, Steegers-Theunissen R P
Abstract excerpt
The importance of maternal smoking in the pathogenesis of oral facial clefts is not clear. Susceptibility to cigarette smoke depends on biotransformation of the toxic compounds by mother and embryo. In a population-based case-control study, we investigated the effects of maternal smoking during the first pregnancy trimester and the interaction with polymorphisms in the biotransformation enzymes cytochrome P450...
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