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Article

[Genetic polymorphisms of GSTM1 and GSTT1 in mothers of children with isolated cleft lip with or without cleft palate].

Przeglad lekarski - 1 Jan 2005

Hozyasz Kamil K, Mostowska Adrianna, Surowiec Zbigniew, Jagodziński Paweł P

Abstract excerpt

Orofacial clefts are one of the most common developmental malformations (OMIM #119530, #119540), which aetiology is very complex and associated with both genetic and environmental factors. One of the main environmental factors increasing the risk of having a child with an oral cleft is maternal cigarette smoking. The effect of maternal smoking may be modified by genes involved in biotransformation of toxic...

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Source

Identifiers

PMID: 16521944

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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[Genetic polymorphisms of GSTM1 and GSTT1 in mothers of children with isolated cleft lip with or without cleft palate].PMID 16521944Read ↗

Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts.Semantic proximity Read ↗

Homozygous deletion of glutathione S-transferase theta 1 and mu 1 increase the risk of non-syndromic oral clefts in a Mexican population.Semantic proximity Read ↗

Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.Semantic proximity Read ↗

Maternal smoking and oral clefts: the role of detoxification pathway genes.Semantic proximity Read ↗

Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction.Semantic proximity Read ↗

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.Semantic proximity Read ↗

Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate.Semantic proximity Read ↗

Association between MTHFR polymorphisms and orofacial clefts risk: a meta-analysis.Semantic proximity Read ↗

Association Between MTHFD1 1958G > A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis.Semantic proximity Read ↗

Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft.Semantic proximity Read ↗

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