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Article

Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.

Antimicrobial agents and chemotherapy - 1 Sept 2011

Pérez-Llarena Francisco José, Kerff Frédéric, Abián Olga, Mallo Susana, Fernández María Carmen, Galleni Moreno, Sancho Javier, Bou Germán

Abstract excerpt

The CTX-M β-lactamases are an increasingly prevalent group of extended-spectrum β-lactamases (ESBL). Point mutations in CTX-M β-lactamases are considered critical for enhanced hydrolysis of cefotaxime. In order to clarify the structural determinants of the activity against cefotaxime in CTX-M β-lactamases, screening for random mutations was carried out to search for decreased activity against cefotaxime, with the...

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Identifiers

PMID: 21730121
DOI: 10.1128/AAC.00298-11
PMCID: PMC3165300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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