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Article

A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.

The Journal of biological chemistry - 18 Jul 2008

Chinnaswamy Sreedhar, Yarbrough Ian, Palaninathan Satheesh, Kumar C T Ranjith, Vijayaraghavan Vinodhini, Demeler Borries, Lemon Stanley M, Sacchettini James C, Kao C Cheng

Abstract excerpt

Mutational analysis of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) template channel identified two residues, Trp(397) and His(428), which are required for de novo initiation but not for extension from a primer. These two residues interact with the Delta1 loop on the surface of the RdRp. A deletion within the Delta1 loop also resulted in comparable activities. The mutant proteins exhibit...

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Identifiers

PMID: 18442978
DOI: 10.1074/jbc.M801490200
PMCID: PMC2459299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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