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Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

16 Dec 2004

Abstract excerpt

Picornaviruses utilize virally encoded RNA polymerase and a uridylylated protein primer to ensure replication of the entire viral genome. The molecular details of this mechanism are not well understood due to the lack of structural information. We report the crystal structure of human rhinovirus 16 3D RNA-dependent RNA polymerase (HRV16 3Dpol) at a 2.4-A resolution, representing the first complete polymerase...

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PMID: 15596823
DOI: 10.1128/jvi.79.1.277-288.2005

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