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Article

Recombinant viral RdRps can initiate RNA synthesis from circular templates.

RNA (New York, N.Y.) - 1 Feb 2006

Ranjith-Kumar C T, Kao C C

Abstract excerpt

The crystal structure of the recombinant hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) revealed extensive interactions between the fingers and the thumb subdomains, resulting in a closed conformation with an established template channel that should specifically accept single-stranded templates. We made circularized RNA templates and found that they were efficiently used by the HCV RdRp to synthesize...

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Share to Catalytic Domain
Share to Guanosine Triphosphate
Share to Heparin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Circular

Share to RNA-Dependent RNA Polymerase

Share to Templates, Genetic

Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 16373481
DOI: 10.1261/rna.2163106
PMCID: PMC1370910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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