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Article

De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities.

Journal of virology - 1 Nov 2004

Ranjith-Kumar C T, Sarisky R T, Gutshall L, Thomson M, Kao C C

Abstract excerpt

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) has several distinct biochemical activities, including initiation of RNA synthesis by a de novo mechanism, extension from a primed template, nontemplated nucleotide addition, and synthesis of a recombinant RNA product from two or more noncovalently linked templates (template switch). All of these activities require specific interaction with...

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Identifiers

PMID: 15507607
DOI: 10.1128/JVI.78.22.12207-12217.2004
PMCID: PMC525054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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