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Article

Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase.

The Journal of biological chemistry - 11 Nov 2005

Kim Young-Chan, Russell William K, Ranjith-Kumar C T, Thomson Michael, Russell David H, Kao C Cheng

Abstract excerpt

Protein-RNA interaction plays a critical role in regulating RNA synthesis by the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp). RNAs of 7 nucleotides (nt) or longer had affinities 5-fold better than an RNA of 5 nt, suggesting a minimal length required for binding. To identify RNA contact sites on the HCV RdRp, a biotinylated 7-nt RNA capable of directing de novo initiation was used in a process that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16166071
DOI: 10.1074/jbc.M508145200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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